概要

顔写真 Name: Kaori ISHIKAWA
Affiliation: Faculty of Life and Environmental Sciences
Specialty: Biological Sciences
Field of Research: Cell biology
Position: Assistant Professor
Degree: Ph.D.(science)
Degree earning University :  Graduate School of Life and Environmental Sciences, University of Tsukuba (March. 2009)
Starting Date: April 1,2014
Mentor: Professor Kazuto NAKADA
Laboratory:

http://mitochondrialbiology.web.fc2.com/index.html

An approach from dysfunction of mitochondrial dynamics to diseases

Mitochondria are dynamic organelle that continuously fuse and divide in cells. Mitochondrial dynamics is functionally important because it ensures the maintenance of number of mitochondria in cells, and distribution of mitochondria into 2 daughter cells after cell division. Moreover, mitochondria exchange their contents (including mitochondrial DNAs (mtDNAs), the products derived from mtDNA, and transported proteins from cytosol) through their fusion and fission to complement each other, and to buffer stresses and damages. In general, pathogenic mtDNA mutation induces decline of ATP production. However, mitochondrial dynamics protects cells from ATP decline by its buffering effects until the pathogenic mutant mtDNAs become dominant. I suppose that dysfunction of mitochondrial dynamics makes disease risks higher. To confirm this hypothesis, now I am trying to establish animal/cell models which harbor both mitochondrial dynamics dysfunction and some disease-inducible mutations. I believe that these models will provide us important keys to understand unknown disease mechanisms.

 

 

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