概要

Name: Atsushi KAWAGUCHI
Affiliation: Faculty of Medicine
Specialty: Major of Medical Science
Field of Research: Virology
Position: Assistant Professor
Degree:

Ph.D. (Medicine)

Degree earning University : Graduate School of Comprehensive Human Sciences,
University of Tsukuba (March 2007)
Starting Date: April 1, 2013
Mentor: Professor Masayuki NOGUCHI
Laboratory: http://www.md.tsukuba.ac.jp/basic-med/kawaguchilab/

Virus-Host interactions determining the pathogenesis and species barrier of influenza virus

 Since viruses have the limited number of viral genes, viruses need to hijack cellular functions and machineries for viral infection. The virus proliferation is dependent on the compatibility between viral factors and host factors in a species- and cell type-specific manner. The cellular machineries, including the innate immunity as anti-viral host defense system, are activated in response to the virus infection. Therefore, the species- and cell type-dependent viral replication and pathogenicity are determined by the competition between virus and host cell (factors).
 Aquatic birds are the reservoir of influenza A viruses in nature and the source for transmission of influenza A viruses to other animal species. However, the avian influenza A viruses hardly replicate in humans, suggesting that it requires an adaptation to human host factors for overcoming the species barrier. Moreover, infected aquatic birds do not show any symptoms to influenza virus. The aim of our study is to clarify the molecular mechanism of species barrier and pathogenesis of influenza virus by focusing on the competition between virus and host cell. We also try to develop an anti-viral compound that can block the viral infection.

 

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