概要

Name: Takashi MATSUZAKA
Affiliation: Faculty of Medicine
Specialty:

Clinical Sciences

Field of Research:

Lifestyle-related disease

Position:

Associate Professor

Degree:

Ph.D. (Medicine)

Degree earning University : Graduate School of Comprehensive Human Sciences,
University of Tsukuba (March 2005)
Starting Date: August 1, 2012
Mentor: Professor Hitoshi SHIMANO
Laboratory:

http://matsuzakalab-tsukuba.org

Development of new strategy for the treatment of lifestyle-related disease by qualitative control of fatty acids

 Now in the world including Japan, the prevalence of obesity and metabolic diseases has grown to epidemic proportions.  Therefore, the understanding of the molecular basis of energy metabolism and development of the effective therapeutic approaches for preventing lifestyle-related diseases are called for immediately.  We are working to understand the molecular mechanisms of which the nutrient signals lead to fatty acid synthesis.  In this process, we identified and characterized a novel mammalian fatty acid elongase, Elovl6, which catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons.  Recently, we have shown that mice with targeted disruption of Elovl6 are resistant to diet-induced insulin resistance, despite their developing obesity.  We suggest that inhibition of this elongase could be a new therapeutic approach for the treatment of diabetes, cardiovascular disease, and other metabolic diseases, even with concurrent obesity.  In this research, we try to elucidate the molecular mechanisms of the regulation of energy metabolism and insulin sensitivity according to changes of fatty acid composition by the analysis of Elovl6 genetically engineered mice, and try to develop new therapeutic approaches for treating lifestyle-related disease based on control of fatty acid composition.

 

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