概要

山田 Name: Tomoko YAMADA
Affiliation: Faculty of Medicine
Specialty: Major of Medical Science
Field of Research: Molecular Neuroscience
Position: Assistant Professor
Degree:

Ph.D.(Engineering)

Degree earning University : Tokyo Institute of Technology (March 2007)
Starting Date: February 1, 2016
Mentor: Associate Professor Masafumi Muratani
Laboratory: http://www.md.tsukuba.ac.jp/basic-med/yamadalab/

Mechanism of neural differentiation in cerebellum through gene regulation

 Brain plays a critical role in human behavior including thinking, memory, and emotion. Brain is composed of many neurons and the other cell types. These neurons form complex neural circuits through synapses and communicate each other, consequently convey information. How does the neural circuit form in development? We are attacking the question using a cerebellum as a model system.
 The cerebellum is important for motor control and contains several neurons including granule neurons and Purkinje cells. These neurons have typical morphology and form synapses with distinct partners. How are newborn neurons integrated to neural circuit in cerebellum in development? To answer the question, we are focused on gene regulation, particularly transcription regulation. 1) We try to understand an epigenetic mechanism which governs gene regulation of neurons in differentiation. 2) Investigate gene expression profile in distinct developmental stages of neurons. These approaches will advance our understanding of differentiation and, therefore, neurodevelopmental disorders of cognition.

 

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